Bernd Kaina Selected Research

A-Form DNA (A-DNA)

4/2022	Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells.
10/2021	Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses.
11/2019	Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69.
2/2006	O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

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Bernd Kaina Research Topics

Disease

99	Neoplasms (Cancer) 03/2024 - 03/2002
36	Glioma (Gliomas) 12/2023 - 02/2006
33	Glioblastoma (Glioblastoma Multiforme) 03/2024 - 02/2006
17	Chromosome Aberrations (Chromosome Abnormalities) 12/2016 - 01/2002
10	Brain Neoplasms (Brain Tumor) 12/2023 - 07/2009
10	Necrosis 03/2021 - 08/2002
9	Carcinogenesis 01/2021 - 02/2004
9	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 11/2013
9	Melanoma (Melanoma, Malignant) 08/2017 - 10/2009
6	Inflammation (Inflammations) 01/2022 - 08/2007
6	Neoplasm Metastasis (Metastasis) 10/2020 - 01/2004
5	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2015 - 09/2006
5	Carcinoma (Carcinomatosis) 07/2010 - 01/2004
4	Astrocytoma (Pilocytic Astrocytoma) 12/2023 - 10/2004
4	Malaria 12/2023 - 05/2010
4	Hypersensitivity (Allergy) 09/2010 - 11/2003
4	Leukemia 09/2006 - 01/2003
3	Genomic Instability 01/2017 - 05/2002
3	Breast Neoplasms (Breast Cancer) 11/2016 - 07/2010
3	Colonic Neoplasms (Colon Cancer) 05/2015 - 01/2003
3	Testicular Neoplasms (Testicular Cancer) 12/2010 - 10/2003
2	Urinary Bladder Neoplasms (Bladder Cancer) 10/2023 - 09/2010
2	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 10/2023 - 01/2010
2	Pain (Aches) 03/2021 - 09/2020
2	Papilloma (Papillomatosis) 03/2014 - 03/2003
2	Blister (Bulla) 07/2007 - 03/2005
2	Lymphoma (Lymphomas) 03/2005 - 01/2004
2	Chromosome Breakage 08/2002 - 03/2002

Drug/Important Bio-Agent (IBA)

46	DNA (Deoxyribonucleic Acid)IBA 03/2024 - 01/2002
44	Temozolomide (Temodar)FDA LinkGeneric 03/2024 - 11/2004
27	Proteins (Proteins, Gene)FDA Link 04/2019 - 03/2002
22	Alkylating AgentsIBA 12/2023 - 04/2003
13	O-(6)-methylguanineIBA 04/2022 - 03/2003
13	MethyltransferasesIBA 01/2021 - 10/2003
10	O(6)-Methylguanine-DNA MethyltransferaseIBA 01/2016 - 03/2003
9	CarcinogensIBA 11/2023 - 10/2003
9	Cisplatin (Platino)FDA LinkGeneric 10/2023 - 12/2004
9	Small Interfering RNA (siRNA)IBA 10/2015 - 12/2007
8	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2018 - 12/2007
8	NimustineIBA 08/2017 - 12/2007
8	fotemustine (Muphoran)IBA 08/2017 - 11/2004
6	ArtesunateIBA 12/2023 - 10/2004
6	Lomustine (CCNU)FDA Link 11/2023 - 10/2014
6	EnzymesIBA 01/2018 - 02/2006
6	GuanineIBA 01/2011 - 10/2003
5	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2020 - 10/2002
5	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2012 - 01/2004
4	Cytostatic AgentsIBA 11/2023 - 03/2002
4	A-Form DNA (A-DNA)IBA 04/2022 - 02/2006
4	Phosphotransferases (Kinase)IBA 12/2017 - 12/2004
4	Glucose (Dextrose)FDA LinkGeneric 10/2017 - 11/2004
4	Carmustine (FIVB)FDA Link 08/2017 - 12/2007
4	Messenger RNA (mRNA)IBA 08/2013 - 05/2012
4	Lovastatin (Mevacor)FDA LinkGeneric 01/2011 - 10/2002
3	DNA Repair EnzymesIBA 01/2021 - 03/2002
3	AzoxymethaneIBA 01/2021 - 12/2010
3	DNA AdductsIBA 08/2017 - 11/2010
3	Indicators and Reagents (Reagents)IBA 02/2017 - 07/2010
3	Transcription Factors (Transcription Factor)IBA 10/2015 - 02/2004
3	SmokeIBA 08/2015 - 07/2010
3	Environmental CarcinogensIBA 10/2013 - 01/2004
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2013 - 10/2005
3	SurvivinIBA 01/2013 - 01/2010
3	Methylnitronitrosoguanidine (MNNG)IBA 11/2010 - 04/2004
3	Cantharidin (Cantharides)IBA 08/2007 - 03/2005
2	Histones (Histone)IBA 04/2022 - 10/2020
2	SenotherapeuticsIBA 01/2022 - 07/2021
2	CurcuminIBA 07/2021 - 01/2021
2	Analgesics (Analgesic Drugs)IBA 03/2021 - 09/2020
2	Methadone (Dolophine)FDA LinkGeneric 03/2021 - 09/2020
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021 - 01/2018
2	Dextrans (Dextran)FDA Link 01/2021 - 01/2018
2	IronIBA 01/2021 - 10/2004
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2018 - 02/2006
2	1-(2-chloroethyl)-1-nitrosourea (CNU)IBA 08/2017 - 11/2016
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2017 - 08/2004
2	Caspase 3 (Caspase-3)IBA 04/2017 - 03/2002
2	Biomarkers (Surrogate Marker)IBA 11/2016 - 10/2003
2	Histone Deacetylase InhibitorsIBA 01/2016 - 06/2011
2	Valproic Acid (Depakote)FDA LinkGeneric 01/2016 - 06/2011
2	Caspase 9IBA 10/2015 - 03/2002
2	Thioctic Acid (Lipoic Acid)IBA 10/2015 - 08/2015
2	Nitroso CompoundsIBA 10/2015 - 11/2013
2	Topoisomerase II InhibitorsIBA 05/2015 - 12/2008
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 07/2014 - 07/2010
2	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 03/2014 - 03/2003
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 04/2013 - 08/2010
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2013 - 12/2008
2	Topoisomerase I InhibitorsIBA 01/2013 - 01/2010
2	AnthracyclinesIBA 05/2012 - 01/2003
2	ArtemisininsIBA 05/2010 - 10/2004
2	artemisinin (artemisinine)IBA 06/2008 - 10/2004
2	Arsenic Trioxide (Trisenox)FDA Link 08/2007 - 09/2004
2	O(6)-benzylguanineIBA 03/2007 - 02/2006
2	E-SelectinIBA 08/2004 - 01/2004

Therapy/Procedure

61	Therapeutics 03/2024 - 10/2002
22	Drug Therapy (Chemotherapy) 12/2023 - 03/2005
7	Radiotherapy 12/2017 - 08/2004
6	Chinese Traditional Medicine (Traditional Chinese Medicine) 12/2023 - 07/2007
2	Aftercare (After-Treatment) 07/2014 - 01/2014